Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Identifieur interne : 000316 ( 2020/Analysis ); précédent : 000315; suivant : 000317Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Auteurs : Manli Wang [République populaire de Chine] ; Ruiyuan Cao [République populaire de Chine] ; Leike Zhang [République populaire de Chine] ; Xinglou Yang [République populaire de Chine] ; Jia Liu [République populaire de Chine] ; Mingyue Xu [République populaire de Chine] ; Zhengli Shi [République populaire de Chine] ; Zhihong Hu [République populaire de Chine] ; Wu Zhong [République populaire de Chine] ; Gengfu Xiao [République populaire de Chine]Source :
- Cell research [ 1748-7838 ] ; 2020.
Descripteurs français
- KwdFr :
- AMP (analogues et dérivés), AMP (pharmacologie), AMP (usage thérapeutique), Alanine (analogues et dérivés), Alanine (pharmacologie), Alanine (usage thérapeutique), Animaux, Antipaludiques (pharmacologie), Antipaludiques (usage thérapeutique), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Cellules Vero, Chloroquine (pharmacologie), Chloroquine (usage thérapeutique), Coronavirus du syndrome respiratoire du Moyen-Orient (), Dosage biologique, Découverte de médicament, Humains, Infections à coronavirus (traitement médicamenteux), Pneumopathie virale (traitement médicamenteux), Sincalide, Virus du SRAS (), Évaluation préclinique de médicament.
- MESH :
- analogues et dérivés : AMP, Alanine.
- pharmacologie : AMP, Alanine, Antipaludiques, Antiviraux, Chloroquine.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : AMP, Alanine, Antipaludiques, Antiviraux, Chloroquine.
- Animaux, Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient, Dosage biologique, Découverte de médicament, Humains, Sincalide, Virus du SRAS, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (pharmacology), Adenosine Monophosphate (therapeutic use), Alanine (analogs & derivatives), Alanine (pharmacology), Alanine (therapeutic use), Animals, Antimalarials (pharmacology), Antimalarials (therapeutic use), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), Betacoronavirus (pathogenicity), Biological Assay, Chlorocebus aethiops, Chloroquine (pharmacology), Chloroquine (therapeutic use), Coronavirus Infections (drug therapy), Drug Discovery, Drug Evaluation, Preclinical, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Pneumonia, Viral (drug therapy), SARS Virus (drug effects), Sincalide, Vero Cells.
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , pharmacology : Adenosine Monophosphate, Alanine, Antimalarials, Antiviral Agents, Chloroquine.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Antimalarials, Antiviral Agents, Chloroquine.
- drug effects : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- Animals, Biological Assay, Chlorocebus aethiops, Drug Discovery, Drug Evaluation, Preclinical, Humans, Sincalide, Vero Cells.
DOI: 10.1038/s41422-020-0282-0
PubMed: 32020029
Affiliations:
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Links to Exploration step
pubmed:32020029Le document en format XML
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(therapeutic use)</term><term>Betacoronavirus (drug effects)</term><term>Betacoronavirus (pathogenicity)</term><term>Biological Assay</term><term>Chlorocebus aethiops</term><term>Chloroquine (pharmacology)</term><term>Chloroquine (therapeutic use)</term><term>Coronavirus Infections (drug therapy)</term><term>Drug Discovery</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Pneumonia, Viral (drug therapy)</term><term>SARS Virus (drug effects)</term><term>Sincalide</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>AMP (analogues et dérivés)</term><term>AMP (pharmacologie)</term><term>AMP (usage thérapeutique)</term><term>Alanine (analogues et dérivés)</term><term>Alanine (pharmacologie)</term><term>Alanine (usage thérapeutique)</term><term>Animaux</term><term>Antipaludiques (pharmacologie)</term><term>Antipaludiques (usage thérapeutique)</term><term>Antiviraux 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xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>AMP</term><term>Alanine</term><term>Antipaludiques</term><term>Antiviraux</term><term>Chloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Assay</term><term>Chlorocebus aethiops</term><term>Drug Discovery</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Sincalide</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Dosage biologique</term><term>Découverte de médicament</term><term>Humains</term><term>Sincalide</term><term>Virus du SRAS</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Pékin</li><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Wang, Manli" sort="Wang, Manli" uniqKey="Wang M" first="Manli" last="Wang">Manli Wang</name></region><name sortKey="Cao, Ruiyuan" sort="Cao, Ruiyuan" uniqKey="Cao R" first="Ruiyuan" last="Cao">Ruiyuan Cao</name><name sortKey="Hu, Zhihong" sort="Hu, Zhihong" uniqKey="Hu Z" first="Zhihong" last="Hu">Zhihong Hu</name><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><name sortKey="Shi, Zhengli" sort="Shi, Zhengli" uniqKey="Shi Z" first="Zhengli" last="Shi">Zhengli Shi</name><name sortKey="Xiao, Gengfu" sort="Xiao, Gengfu" uniqKey="Xiao G" first="Gengfu" last="Xiao">Gengfu Xiao</name><name sortKey="Xu, Mingyue" sort="Xu, Mingyue" uniqKey="Xu M" first="Mingyue" last="Xu">Mingyue Xu</name><name sortKey="Yang, Xinglou" sort="Yang, Xinglou" uniqKey="Yang X" first="Xinglou" last="Yang">Xinglou Yang</name><name sortKey="Zhang, Leike" sort="Zhang, Leike" uniqKey="Zhang L" first="Leike" last="Zhang">Leike Zhang</name><name sortKey="Zhong, Wu" sort="Zhong, Wu" uniqKey="Zhong W" first="Wu" last="Zhong">Wu Zhong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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